Detection of Unexpected Isoforms of Human Chorionic Gonadotropin by Qualitative Tests
نویسندگان
چکیده
منابع مشابه
Detection of unexpected isoforms of human chorionic gonadotropin by qualitative tests.
To the Editor: Human chorionic gonadotropin (CG) is a heterodimeric glycoprotein hormone composed of noncovalently associated and subunits that are synthesized by trophoblastic tissue in pregnancy. Systemic modification and degradation of the intact CG molecule and subunits leads to molecular heterogeneity in the serum and urine (1 ). The subunit is a component of nicked CG (CGn), CG -subunit (...
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BACKGROUND Early diagnosis of ectopic pregnancy uses ultrasound with serial measurements of total human chorionic gonadotropin (hCG). The objective of this study was to explore the possibility that an isolated measurement of hCG isoforms/subunits rather than total hCG could be used as a single test for ectopic pregnancy. METHODS Total and intact hCG, free hCG beta- and alpha-subunits (hCGbeta...
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Human Chorionic Gonadotropin
A highly active preparation of human chorionic gonadotropin has been obtained by simple methods of column chromatography on diethylaminoethyl Sephadex and Sephadex G-100. The preparation appeared homogeneous by disc and immunoelectrophoresis, ultracentrifugation, and end group analysis. It assayed at 12,000 i.u. per mg by the rat prostrate gland and accessory sex organ method. The ~20,~ value w...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2007
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2007.085399